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We do not know yet why men with prostate most cancers develop androgen resistance, but a number one concept is that prostate tumors contain different types of cells, some of which are resistant to hormone therapy. Abbreviations: CRF, case report form; ECOG PS, Japanese Cooperative Oncology Group performance status; REALITY-P, Functional Assessment of Cancer Remedy-Prostate; M0, nonmetastatic; M1, metastatic; PSA, prostate-particular antigen.
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